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Sleeping pills stop the brain’s system for cleaning out waste

20 January 2025 at 16:54

Our bodies rely on their lymphatic system to drain excessive fluids and remove waste from tissues, feeding those back into the blood stream. It’s a complex yet efficient cleaning mechanism that works in every organ except the brain. β€œWhen cells are active, they produce waste metabolites, and this also happens in the brain. Since there are no lymphatic vessels in the brain, the question was what was it that cleaned the brain,” Natalie Hauglund, a neuroscientist at Oxford University who led a recent study on the brain-clearing mechanism, told Ars.

Earlier studies done mostly on mice discovered that the brain had a system that flushed its tissues with cerebrospinal fluid, which carried away waste products in a process called glymphatic clearance. β€œScientists noticed that this only happened during sleep, but it was unknown what it was about sleep that initiated this cleaning process,” Hauglund explains.

Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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Google’s DeepMind is building an AI to keep us from hating each other

24 October 2024 at 23:36

An unprecedented 80 percent of Americans, according to a recent Gallup poll, think the country is deeply divided over its most important values ahead of the November elections. The general public’s polarization now encompasses issues like immigration, health care, identity politics, transgender rights, or whether we should support Ukraine. Fly across the Atlantic and you’ll see the same thing happening in the European Union and the UK.

To try to reverse this trend, Google’s DeepMind built an AI system designed to aid people in resolving conflicts. It’s called the Habermas Machine after JΓΌrgen Habermas, a German philosopher who argued that an agreement in a public sphere can always be reached when rational people engage in discussions as equals, with mutual respect and perfect communication.

But is DeepMind’s Nobel Prize-winning ingenuity really enough to solve our political conflicts the same way they solved chess or StarCraft or predicting protein structures? Is it even the right tool?

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