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Our bodies rely on their lymphatic system to drain excessive fluids and remove waste from tissues, feeding those back into the blood stream. It’s a complex yet efficient cleaning mechanism that works in every organ except the brain. “When cells are active, they produce waste metabolites, and this also happens in the brain. Since there are no lymphatic vessels in the brain, the question was what was it that cleaned the brain,” Natalie Hauglund, a neuroscientist at Oxford University who led a recent study on the brain-clearing mechanism, told Ars.
Earlier studies done mostly on mice discovered that the brain had a system that flushed its tissues with cerebrospinal fluid, which carried away waste products in a process called glymphatic clearance. “Scientists noticed that this only happened during sleep, but it was unknown what it was about sleep that initiated this cleaning process,” Hauglund explains.
Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.
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SpaceX launched an upgraded version of its massive Starship rocket from South Texas on Thursday, but the flight ended less than nine minutes later after engineers lost contact with the spacecraft.
For a few moments, SpaceX officials discussing the launch on the company's live webcast were unsure of the outcome of the test flight. However, within minutes, residents and tourists in the Turks and Caicos Islands, Haiti, the Dominican Republic, and Puerto Rico shared videos showing a shower of debris falling through the atmosphere along Starship's expected flight corridor.
The videos confirmed Starship—the rocket's upper stage—broke apart in space, or experienced a "rapid unscheduled disassembly" in SpaceX-speak. This happened well short of the spacecraft's planned trajectory, which would have seen it fly halfway around the world and splash down in the Indian Ocean after more than an hour of flight.
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If you’re having trouble sleeping at night, have you tried to induce total existential dread by contemplating the end of the entire Universe?
If not, here’s a rundown of five ideas exploring how “all there is” might become “nothing at all.”
Enjoy.
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