Enlarge (credit: Aurich Lawson | Getty Images)

Most living organisms easily surpass machines when it comes to navigating real-world environments and adaptability to changing conditions. One way to bridge that gap is building biohybrid robots that merge synthetic machinery with biological components like animal muscles, bacteria, or plants.

But living muscles are very hard to keep alive in a machine, bacteria have a very short lifespan, and plants tend to react to things a bit slowly, like Ents in The Lord of the Rings. So, a team of scientists at Cornell University went down a different path and built biohybrid robots controlled by fungi, specifically, oyster mushrooms.

Understanding mushrooms’ signals

Robots controlled by fungi, despite giving strong Last of Us vibes, are a good idea on paper. Fungi are very easy to sustain and can live pretty much everywhere, including extreme environments like the Arctic, or even amid nuclear contamination. They're also cheap to culture in large quantities and excel at reacting to environmental cues like exposure to light.

Enlarge / Zihao Ou, who helped develop this solution, holds a tube of it.

One key challenge in medical imaging is to look past skin and other tissue that are opaque to see internal organs and structures. This is the reason we need things like ultrasonography, magnetic resonance, or X-rays. There are chemical clearing agents that can make tissue transparent, like acrylamide or tetrahydrofuran, but they are almost never used in living organisms because they’re either highly toxic or can dissolve away essential biomolecules.

But now, a team of Stanford University scientists has finally found an agent that can reversibly make skin transparent without damaging it. This agent was tartrazine, a popular yellow-orange food dye called FD&C Yellow 5 that is notably used for coloring Doritos.

Playing with light

We can’t see through the skin because it is a complex tissue comprising aqueous-based components such as cell interiors and other fluids, as well as protein and lipids. The refractive index is a value that indicates how much light slows down (on average, of course) while going through a material compared to going through a vacuum. The refractive index of those aqueous components is low, while the refractive index of the proteins and lipids is high. As a result, light traveling through skin constantly bends as it endlessly crosses the boundary between high and low refractive index materials.

Enlarge (credit: BirdImages)

It seems like common sense that being smart should increase the chances of survival in wild animals. Yet for a long time, scientists couldn’t demonstrate that because it was unclear how to tell exactly if a lion or a crocodile or a mountain chickadee was actually smart or not. Our best shots, so far, were looking at indirect metrics like brain size or doing lab tests of various cognitive skills such as reversal learning, an ability that can help an animal adapt to a changing environment.

But a new, large-scale study on wild mountain chickadees, led by Joseph Welklin, an evolutionary biologist at the University of Nevada, showed that neither brain size nor reversal learning skills were correlated with survival. What mattered most for chickadees, small birds that save stashes of food, was simply remembering where they cached all their food. A chickadee didn’t need to be a genius to survive; it just needed to be good at its job.

Testing bird brains

“Chickadees cache one food item in one location, and they do this across a big area. They can have tens of thousands of caches. They do this in the fall and then, in the winter, they use a special kind of spatial memory to find those caches and retrieve the food. They are little birds, weight is like 12 grams, and they need to eat almost all the time. If they don’t eat for a few hours, they die,” explains Vladimir Pravosudov, an ornithologist at the University of Nevada and senior co-author of the study.

Enlarge / High pressure ices near the crust are a feature of water-rich worlds.` (credit: Benoit Gougeon (University of Montreal))

The possibility that there is liquid water on an exoplanet’s surface usually flags it as “potentially habitable,” but the reality is that too much water might prevent life from taking hold.

“On Earth, the ocean is in contact with some rock. If we have too much water, it creates high-pressure ice underneath the ocean, which separates it from the planet’s rocky interior,” said Caroline Dorn, a geophysicist at ETH Zurich, Switzerland, who led new research in exoplanet interiors.

This high-pressure ice prevents minerals and chemical compounds from being exchanged between the rocks and the water. In theory, that should make the ocean barren and lifeless. But Dorn’s team argues that even exoplanets that have enough water to form such high-pressure ice can host life if the majority of the water is not stored in the surface oceans but is held much deeper in the planet’s core. The water in the core can’t sustain life—it’s not even in its molecular form there. But it means that a substantial fraction of a planet’s water isn’t on the surface, which makes the surface oceans a little more shallow and prevents high-pressure ice from forming at their bottom.

Enlarge / For now, "you should see a doctor" remains good advice.

ChatGPT was able to pass some of the United States Medical Licensing Exam (USMLE) tests in a study done in 2022. This year, a team of Canadian medical professionals checked to see if it’s any good at actual doctoring. And it’s not.

ChatGPT vs. Medscape

“Our source for medical questions was the Medscape questions bank,” said Amrit Kirpalani, a medical educator at the Western University in Ontario, Canada, who led the new research into ChatGPT’s performance as a diagnostic tool. The USMLE contained mostly multiple-choice test questions; Medscape has full medical cases based on real-world patients, complete with physical examination findings, laboratory test results, and so on.

The idea behind it is to make those cases challenging for medical practitioners due to complications like multiple comorbidities, where two or more diseases are present at the same time, and various diagnostic dilemmas that make the correct answers less obvious. Kirpalani’s team turned 150 of those Medscape cases into prompts that ChatGPT could understand and process.

Enlarge / Jessica Watkins gets to work on the ISS (credit: NASA)

“Archeology really is a perspective on material culture we use as evidence to understand how humans adapt to their environment, to the situations they are in, and to each other. There is no place, no time that is out of bounds,” says Justin Walsh, an archeologist at Chapman University who led the first off-world archeological study on board the ISS.

Walsh’s and his team wanted to understand, document, and preserve the heritage of the astronaut culture at one of the first permanent space habitats. “There is this notion about astronauts that they are high achievers, highly intelligent, and highly trained, that they are not like you and me. What we learned is that they are just people, and they want the comforts of home,” Walsh says.

Disposable cameras and garbage

“In 2008, my student in an archeology class raised her hand and said, ‘What about stuff in space, is that heritage?’ I said, ‘Oh my God, I’ve never thought of this before, but yes,’” Walsh says. “Think of Tranquility base—it’s an archeological site. You could go back there, and you could reconstruct not only the specific activities of Neil Armstrong and Buzz Aldrin, but you could understand the engineering culture, the political culture, etc. of the society that created that equipment, sent it to the Moon, and left it there.”

Enlarge / Muscle atrophy is a known hazard of spending time on the International Space Station. (credit: NASA)

Muscle-on-chip systems are three-dimensional human muscle cell bundles cultured on collagen scaffolds. A Stanford University research team sent some of these systems to the International Space Station to study the muscle atrophy commonly observed in astronauts.

It turns out that space triggers processes in human muscles that eerily resemble something we know very well: getting old. “We learned that microgravity mimics some of the qualities of accelerated aging,” said Ngan F. Huang, an associate professor at Stanford who led the study.

Space-borne bioconstructs

“This work originates from our lab’s expertise in regenerative medicine and tissue engineering. We received funding to do a tissue engineering experiment on the ISS, which really helped us embark on this journey, and became curious how microgravity affects human health,” said Huang. So her team got busy designing the research equipment needed to work onboard the space station. The first step was building the muscle-on-chip systems.

Enlarge / The environment you're eating in can influence what you taste, and space is no exception. (credit: NASA)

Astronauts on the ISS tend to favor spicy foods and top other foods with things like tabasco or shrimp cocktail sauce with horseradish. “Based on anecdotal reports, they have expressed that food in space tastes less flavorful. This is the way to compensate for this,” said Grace Loke, a food scientist at the RMIT University in Melbourne, Australia.

Loke’s team did a study to take a closer look at those anecdotal reports and test if our perception of flavor really changes in an ISS-like environment. It likely does, but only some flavors are affected.

Tasting with all senses

“There are many environmental factors that could contribute to how we perceive taste, from the size of the area to the color and intensity of the lighting, the volume and type of sounds present, the way our surroundings smell, down to even the size and shape of our cutlery. Many other studies covered each of these factors in some way or another,” said Loke.

Enlarge / Artist concept of the Demonstration for Rocket to Agile Cislunar Operations (DRACO) spacecraft. (credit: DARPA)

Phoebus 2A, the most powerful space nuclear reactor ever made, was fired up at Nevada Test Site on June 26, 1968. The test lasted 750 seconds and confirmed it could carry first humans to Mars. But Phoebus 2A did not take anyone to Mars. It was too large, it cost too much, and it didn’t mesh with Nixon’s idea that we had no business going anywhere further than low-Earth orbit.

But it wasn’t NASA that first called for rockets with nuclear engines. It was the military that wanted to use them for intercontinental ballistic missiles. And now, the military wants them again.

Nuclear-powered ICBMs

The work on nuclear thermal rockets (NTRs) started with the Rover program initiated by the US Air Force in the mid-1950s. The concept was simple on paper. Take tanks of liquid hydrogen and use turbopumps to feed this hydrogen through a nuclear reactor core to heat it up to very high temperatures and expel it through the nozzle to generate thrust. Instead of causing the gas to heat and expand by burning it in a combustion chamber, the gas was heated by coming into contact with a nuclear reactor.

Enlarge / Human Neuron, Digital Light Microscope. (Photo By BSIP/Universal Images Group via Getty Images) (credit: BSIP/Universal Images Group via Getty Images)

“Language is a huge field, and we are novices in this. We know a lot about how different areas of the brain are involved in linguistic tasks, but the details are not very clear,” says Mohsen Jamali, a computational neuroscience researcher at Harvard Medical School who led a recent study into the mechanism of human language comprehension.

“What was unique in our work was that we were looking at single neurons. There is a lot of studies like that on animals—studies in electrophysiology, but they are very limited in humans. We had a unique opportunity to access neurons in humans,” Jamali adds.

Probing the brain

Jamali’s experiment involved playing recorded sets of words to patients who, for clinical reasons, had implants that monitored the activity of neurons located in their left prefrontal cortex—the area that’s largely responsible for processing language. “We had data from two types of electrodes: the old-fashioned tungsten microarrays that can pick the activity of a few neurons; and the Neuropixel probes which are the latest development in electrophysiology,” Jamali says. The Neuropixels were first inserted in human patients in 2022 and could record the activity of over a hundred neurons.