On May 7, 2011, Georgia resident Tonya Brand noticed a pain on the inside of her right thigh. As the pain grew worse in the 4- to 5-inch area of her leg, she headed to a hospital. There, doctors suspected she had a blood clot. But an ultrasound the next day failed to find one. Instead, it revealed a mysterious toothpick-sized object lodged in Brand's leg.

Over the next few weeks, the painful area became a bulge, and on June 17, Brand put pressure on it. Unexpectedly, the protrusion popped, and a 1.5-inch metal wire came poking out of her leg, piercing her skin.

The piece of metal was later determined to be part of a metal filter she had implanted in a vein in her abdomen more than two years earlier, in March 2009, according to a lawsuit Brand filed. The filter was initially placed in her inferior vena cava (IVC), the body's largest vein tasked with bringing deoxygenated blood from the lower body back up to the heart. The filter is intended to catch blood clots, preventing them from getting into the lungs, where they could cause a life-threatening pulmonary embolism. Brand got the IVC filter ahead of a spinal surgery she had in 2009, which could boost her risk of clots.

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Patients in China will be able to purchase the blockbuster weight-loss drug Wegovy for 1,400 yuan, or about $193, just a fraction of the US list price of $1,349, according to media reports.

The price in China is in line with pricing elsewhere outside of the US. As Sen. Bernie Sanders (I-Vt.) noted in a September Senate hearing, Wegovy, made by Novo Nordisk, is sold for $265 in Canada, $186 in Denmark, $137 in Germany, and just $92 in the United Kingdom. In the hearing, Sanders and other senators grilled Novo Nordisk CEO Lars Jørgensen on the "outrageously high prices" in the US of Wegovy and the company's other popular GLP-1 drug, Ozempic, used for diabetes.

"What we are dealing with today is not just an issue of economics, it is not just an issue of corporate greed. It is a profound moral issue," Sanders said in opening remarks about the prices of the highly effective drugs.

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Scientists could win back trust lost during the COVID-19 pandemic if they just showed a little intellectual humility, according to a study published Monday in Nature Human Behavior.

It's no secret that scientists—and the science generally—took a hit during the health crisis. Public confidence in scientists fell from 87 percent in April 2000 to a low of 73 percent in October 2023, according to survey data from the Pew Research Center. And the latest Pew data released last week suggests it will be an uphill battle to regain what was lost, with confidence in scientists only rebounding three percentage points, to 76 percent in a poll from October.

Building trust

The new study in Nature Human Behavior may guide the way forward, though. The study encompasses five smaller studies probing the perceptions of scientists' trustworthiness, which previous research has linked to willingness to follow research-based recommendations.

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Without question, inactivity is bad for us. Prolonged sitting is consistently linked to higher risks of cardiovascular disease and death. The obvious response to this frightful fate is to not sit— move. Even a few moments of exercise can have benefits, studies suggest. But in our modern times, sitting is hard to avoid, especially at the office. This has led to a range of strategies to get ourselves up, including the rise of standing desks. If you have to be tethered to a desk, at least you can do it while on your feet, the thinking goes.

However, studies on whether standing desks are beneficial have been sparse and sometimes inconclusive. Further, prolonged standing can have its own risks, and data on work-related sitting has also been mixed. While the final verdict on standing desks is still unclear, two studies out this year offer some of the most nuanced evidence yet about the potential benefits and risks of working on your feet.

Take a seat

For years, studies have pointed to standing desks improving markers for cardiovascular and metabolic health, such as lipid levels, insulin resistance, and arterial flow-mediated dilation (the ability of arteries to widen in response to increased blood flow). But it's unclear how significant those improvements are to averting bad health outcomes, such as heart attacks. One 2018 analysis suggested the benefits might be minor.

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A British Columbia teen who contracted Canada's first known human case of H5 bird flu has deteriorated swiftly in recent days and is now in critical condition, health officials reported Tuesday.

The teen's case was announced Saturday by provincial health officials, who noted that the teen had no obvious exposure to animals that could explain an infection with the highly pathogenic avian influenza. The teen tested positive for H5 bird flu at BC's public health laboratory, and the result is currently being confirmed by the National Microbiology Laboratory in Winnipeg.

The teen's case reportedly began with conjunctivitis, echoing the H5N1 human case reports in the US. The case then progressed to fever and cough, and the teen was admitted to BC's Children's hospital late Friday. The teen's condition varied throughout the weekend but had taken a turn for the worse by Tuesday, according to BC provincial health officer Bonnie Henry.

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If you need any inspiration for cutting loose and relaxing this weekend, look no further than a free-wheeling troop of monkeys that broke out of their South Carolina research facility Wednesday and, as of noon Friday, were still "playfully exploring" with their newfound freedom.

In an update Friday, the police department of Yemassee, SC said that the 43 young, female rhesus macaque monkeys are still staying around the perimeter of the Alpha Genesis Primate Research Facility. "The primates are exhibiting calm and playful behavior, which is a positive indication," the department noted.

The fun-loving furballs got free after a caretaker "failed to secure doors" at the facility.

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In a long-sought move, the Food and Drug Administration on Thursday formally began the process of abandoning oral doses of a common over-the-counter decongestant, which the agency concluded last year is not effective at relieving stuffy noses.

Specifically, the FDA issued a proposed order to remove oral phenylephrine from the list of drugs that drugmakers can include in over-the-counter products—also known as the OTC monograph. Once removed, drug makers will no longer be able to include phenylephrine in products for the temporary relief of nasal congestion.

"It is the FDA’s role to ensure that drugs are safe and effective," Patrizia Cavazzoni, director of the FDA’s Center for Drug Evaluation and Research, said in a statement. "Based on our review of available data and consistent with the advice of the advisory committee, we are taking this next step in the process to propose removing oral phenylephrine because it is not effective as a nasal decongestant."

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Kids and teens can make some pretty hairbrained choices sometimes. But when a kid's choice is to engage in a TikTok challenge that threatens their life, psychiatrists can struggle to understand if it was just an exasperating poor choice born out of impulsivity and immaturity or something darker—an actual suicide attempt.

In a Viewpoint published today in JAMA Psychiatry, two psychiatrists from the University of Tennessee Health Science Center at Memphis raise the alarm about the dangers and complexities of TikTok challenges. They're an "emerging public health concern" for kids, the psychiatrists write, and they're blurring the lines between unintentional injuries and suicide attempts in children and teens.

The child and adolescent psychiatrists Onomeasike Ataga and Valerie Arnold say that their psychiatry team first saw injuries from TikTok challenges during the COVID-19 pandemic, but the trend has continued since the pandemic eased. Over recent years, they've seen children and teens hospitalized from a variety of challenges, including the "blackout challenge," in which participants attempt to choke themselves until they pass out; the "Benadryl challenge," in which participants ingest a large amount of the allergy medicine to get high and hallucinate; and the "fire challenge," in which participants pour a flammable liquid on their body and light it on fire. In these cases, the psychiatry team is sometimes called in to help assess whether the children and teens had an intent to self-harm. It's often hard to determine—and thus hard to decide on treatment recommendations.

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A Massachusetts spa owner has been arrested for what prosecutors describe as a blundering scheme in which she conspicuously smuggled counterfeit Botox and skin fillers into the US, then peddled them to clients by falsely claiming to be a nurse with a degree from "Havard" [sic] and a license from the state's "Estate Board."

Nevertheless, the woman—Rebecca Fadanelli, 38, of Stoughton—allegedly performed over 2,700 illegal injections between 2021 and 2024, raking in over $900,000 with the scam.

According to an affidavit from a special agent with the Food and Drug Administration, Fadanelli was smuggling in counterfeit Botox and fillers from China and Brazil. Between November 2023 and March 2024, Customs and Border Protection (CBP) seized at least six parcels from China addressed to Fadanelli or her employees. The packages included various counterfeit injectable drugs, including products labeled as Botox and skin fillers Sculptra and Juvederm.

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The Food and Drug Administration is warning consumers not to use any drugs made by a compounding pharmacy in California after regulators realized the pharmacy was making drugs that need to be sterile—particularly injectable drugs—without using sterile ingredients or any sterilization steps.

The products made by the pharmacy, Fullerton Wellness LLC, in Ontario, California, include semaglutide, which is intended to mimic brand-name weight-loss and diabetes drugs Wegovy and Ozempic. Fullerton also made tirzepatide, which is intended to mimic weight-loss and diabetes drugs Zepbound and Mounjaro.

The FDA became aware of the problem after a patient submitted a complaint to the regulator that a vial of semaglutide from Fullerton Wellness had an unidentified "black particulate" floating in it. Semaglutide, like tirzepatide, is injected under the skin and is intended to be sterile.

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The western North Carolina plant that makes 60 percent of the country's intravenous fluid supply has restarted its highest-producing manufacturing line after being ravaged by flooding brought by Hurricane Helene last month.

While it's an encouraging sign of recovery as hospitals nationwide struggle with shortages of fluids, supply is still likely to remain tight for the coming weeks.

IV fluid-maker Baxter Inc, which runs the Marion plant inundated by Helene, said Thursday that the restarted production line could produce, at peak, 25 percent of the plant's total production and about 50 percent of the plant's production of one-liter IV solutions, the product most commonly used by hospitals and clinics.

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Residents in the Southwest District Health in Idaho are no longer able to get COVID-19 vaccines from public health clinics after the district's board of directors voted 4–3 recently to stop administering the shot.

The vote came during a hearing swamped by misinformation and conspiracy theories about the lifesaving vaccines. It's a chilling reminder of how dangerous anti-vaccine sentiment and misinformation have infested communities nationwide, causing vaccination rates to slip across the country and making way for deadly outbreaks of preventable diseases.

Safety net

In a hearing last week, Perry Jansen, the health district’s medical director, gave the only presentation that favored keeping COVID-19 vaccines available through district clinics. He echoed the points that all health experts and major health organizations, including the Centers for Disease Control and Prevention, have pointed out for years: that COVID-19 vaccines have proven to be safe, lifesaving immunizations that are recommended for everyone ages 6 months and up.

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Slivered onions are the likely source of the multi-state E. coli outbreak linked to McDonald's Quarter Pounder burgers that continues to grow, the Centers for Disease Control and Prevention announced Wednesday.

Onions were one of two primary suspects when the CDC announced the outbreak on October 22, with the other being the beef patties used on the burgers. But onions quickly became the leading suspect. The day after the CDC's announcement, McDonald's onion supplier, Taylor Farms, recalled peeled and diced yellow onion products, and several other fast food chains took onions off the menu as a precaution. (No other restaurants have been linked to the outbreak to date.)

According to the CDC, traceback information and epidemiological data collected since then have all pointed to the onions, and, according to McDonald's, state and federal testing of the beef patties has all come back negative.

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For some, microwaving fish in the employee lunch room is the ultimate work faux pas. But for one (likely mortified) employee of a seafood distribution plant in Maryland, it's probably causing a mass poisoning with the homemade noodle dish they brought to share for lunch. The dish sickened 46 employees, spurring their employer to hastily release a statement assuring customers that it wasn't the company's food that caused the illnesses.

On October 21, first responders and paramedics arrived at the NAFCO Wholesale Fish Distribution Facility in Jessup, where dozens of employees had abruptly fallen ill about three hours after lunch. Helicopter footage of the event captured images of workers around picnic tables outside the plant, some doubled over and with their heads down.

Ultimately, 46 people were sickened, and at least 26 were treated at an area hospital with symptoms of food poisoning, according to The Baltimore Banner. They all recovered.

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Dozens of people in Wisconsin have been sickened and at least five needed emergency medical services after inadvertently eating pizza tainted with Delta-9-tetrahydrocannabinol (THC), the principal psychoactive compound in cannabis, officials of Public Health Madison & Dane County reported late Friday.

The contamination, which health officials called "unintentional," occurred at Famous Yeti’s Pizza in Stoughton between October 22 and October 24. In a news release, the local health department advised customers to throw away any pizza they had from the restaurant during that time period.

"We want to be sure anyone who has this pizza on hand throws it away so they don't get sick," Bonnie Armstrong, director of Environmental Health at Public Health Madison & Dane County, said in the release. "If you ate the pizza and are experiencing THC-related symptoms, please contact your health care provider or call 911 if your symptoms worsen."

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News and talk of GLP-1 drugs are everywhere these days—from their smash success in treating Type 2 diabetes and obesity to their astronomical pricing, drug shortages, compounding disputes, and what sometimes seems like an ever-growing list of other conditions the drugs could potentially treat. There are new headlines every day.

Although the drugs have abruptly stolen the spotlight in recent years, researchers have been toiling away at developing and understanding them for decades, stretching back to the 1970s. Despite all the time and effort, the drugs still hold mysteries and unknowns. For instance, researchers thought for years that they worked directly in the gut to decrease blood sugar levels and make people feel full. After all, the drugs mimic an incretin hormone, glucagon-like peptide-1, that does exactly that. But, instead, studies have since found that they work in the brain.

In fact, the molecular receptors for GLP-1 are sprinkled in many places around the body. They're found in the central nervous system, the heart, blood vessels, liver, and kidney. Their presence in the brain even plays a role in inflammation. As such, research on GLP-1 continues to flourish as scientists work to understand the role it could play in treating a range of other chronic conditions.

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Big-name fast food chains, including Taco Bell, KFC, Pizza Hut, and Burger King, are reportedly pulling onions off their menus in certain locations amid a deadly, multistate outbreak of E. coli O157:H7 linked to McDonald's Quarter Pounders.

Though the source of the outbreak bacteria has not been confirmed by the Centers for Disease Control and Prevention, the leading suspects are the beef patties and the sliced onions used on the popular burger.

On Wednesday, McDonald's onion supplier Taylor Farms recalled peeled and diced yellow onion products, according to a notice from US Foods, a supplier of food service operations.

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As H5N1 bird flu continues to spread wildly among California dairy herds and farmworkers, federal health officials on Thursday offered some relatively good news about Missouri: The wily avian influenza virus does not appear to have spread from the state's sole human case, which otherwise remains a mystery.

On September 6, the Missouri Health department announced that a person with underlying health conditions tested positive for bird flu, and later testing indicated that it was an H5N1 strain related to the one currently circulating among US dairy cows. But, state and federal health officials were—and still are—stumped as to how that person became infected. The person had no known contact with infected animals and no contact with any obviously suspect animal products. No dairy herds in Missouri have tested positive, and no poultry farms had reported recent outbreaks, either. To date, all other human cases of H5N1 have been among farmworkers who had contact with H5N1-infected animals.

But aside from the puzzle, attention turned to the possibility that the unexplained Missouri case had passed on the infection to those around them. A household contact had symptoms at the same time as the person—aka the index case—and at least six health care workers developed illnesses after interacting with the person. One of the six had tested negative for bird flu around the time of their illness, but questions remained about the other five.

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One person is dead and 48 others across 10 states have been sickened in an E. coli O157:H7 outbreak that appears to be linked to McDonald's Quarter Pounders and the slivered onions used on the burgers, according to the Centers for Disease Control and Prevention.

McDonald's has paused distribution of the slivered onions and removed Quarter Pounders from the menus of restaurants in areas known to be affected. As of now, those areas include Colorado, Kansas, Utah, and Wyoming, as well as portions of Idaho, Iowa, Missouri, Montana, Nebraska, Nevada, New Mexico, and Oklahoma.

However, the CDC was quick to note that the size and span of the outbreak are likely larger than is currently known. "This outbreak may not be limited to the states with known illnesses, and the true number of sick people is likely much higher than the number reported," the agency said in its outbreak notice posted Tuesday afternoon.

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