As the Popo Agie River wends its way down from the glaciers atop Wyoming’s Wind River Mountains toward the city of Lander, it flows into a limestone cave and disappears. The formation, known as the Sinks, spits the river back out at another feature called the Rise a quarter of a mile east, a little more voluminous and a little warmer, with brown and rainbow trout weighing as much as 10 pounds mingling in its now smooth pools. The quarter-mile journey from the Sinks to the Rise takes the river two hours.

Scientists first discovered this quirk of the middle fork of the Popo Agie (pronounced puh-po zuh) in 1983 by pouring red dye into the river upstream and waiting for it to resurface. Geologists attribute the river’s mysterious delay to the water passing through exceedingly small crevasses in the rock that slow its flow.

Like many rivers in the arid West, the Popo Agie is an important aquifer. Ranchers, farmers, businesses, and recreationists rely on detailed data about it—especially day-to-day streamflow measurements. That’s exactly the type of empirical information collected by the National Oceanic and Atmospheric Administration (NOAA).

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It’s Halloween. You’ve just finished trick-or-treating and it’s time to assess the haul. You likely have a favorite, whether it’s chocolate bars, peanut butter cups, those gummy clusters with Nerds on them, or something else.

For some people, including me, one piece stands out—the Snickers bar, especially if it’s full-size. The combination of nougat, caramel, and peanuts coated in milk chocolate makes Snickers a popular candy treat.

As a food engineer studying candy and ice cream at the University of Wisconsin-Madison, I now look at candy in a whole different way than I did as a kid. Back then, it was all about shoveling it in as fast as I could.

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In the 1940s, scientists at the recently established National Cancer Institute were trying to breed mice that could inform our understanding of cancer, either because they predictably developed certain cancers or were surprisingly resistant.

The team spotted a peculiar litter in which some baby mice had short, kinked tails and misplaced ribs growing out of their neck bones. The strain of mice, nicknamed “tail short,” has been faithfully bred ever since, in the hope that one day, research might reveal what was the matter with them.

After more than 60 years, researchers finally got their answer, when Maria Barna, a developmental biologist then at the University of California San Francisco, found that the mice had a genetic mutation that caused a protein to disappear from their ribosomes—the places in cells where proteins are made.

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For Cherise Irons, chocolate, red wine, and aged cheeses are dangerous. So are certain sounds, perfumes and other strong scents, cold weather, and thunderstorms. Stress and lack of sleep, too.

She suspects all of these things can trigger her migraine attacks, which manifest in a variety of ways: pounding pain in the back of her head, exquisite sensitivity to the slightest sound, even blackouts and partial paralysis.

Irons, 48, of Coral Springs, Florida, once worked as a school assistant principal. Now, she’s on disability due to her migraine. Irons has tried so many migraine medications she’s lost count—but none has helped for long. Even a few of the much-touted new drugs that have quelled episodes for many people with migraine have failed for Irons.

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At the University of Toronto, just across the street from the football stadium, workers are putting up a 14-story building with space for classrooms and faculty offices. What’s unusual is how they’re building it — by bolting together giant beams, columns, and panels made of manufactured slabs of wood.

As each wood element is delivered by flatbed, a tall crane lifts it into place and holds it in position while workers attach it with metal connectors. In its half-finished state, the building resembles flat-pack furniture in the process of being assembled.

The tower uses a new technology called mass timber. In this kind of construction, massive, manufactured wood elements that can extend more than half the length of a football field replace steel beams and concrete. Though still relatively uncommon, it is growing in popularity and beginning to pop up in skylines around the world.

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The human mind may find it difficult to conceptualize: a cosmic cloud so colossal it surrounds the Sun and eight planets as it extends trillions of miles into deep space.

The spherical shell known as the Oort Cloud is, for all practical purposes, invisible. Its constituent particles are spread so thinly, and so far from the light of any star, including the Sun, that astronomers simply cannot see the cloud, even though it envelops us like a blanket.

It is also theoretical. Astronomers infer the Oort Cloud is there because it’s the only logical explanation for the arrival of a certain class of comets that sporadically visit our solar system. The cloud, it turns out, is basically a gigantic reservoir that may hold billions of icy celestial bodies.

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On October 10, 2018, Tyndall Air Force Base on the Gulf of Mexico—a pillar of American air superiority—found itself under aerial attack. Hurricane Michael, first spotted as a Category 2 storm off the Florida coast, unexpectedly hulked up to a Category 5. Sustained winds of 155 miles per hour whipped into the base, flinging power poles, flipping F-22s, and totaling more than 200 buildings. The sole saving grace: Despite sitting on a peninsula, Tyndall avoided flood damage. Michael’s 9- to 14-foot storm surge swamped other parts of Florida. Tyndall’s main defense was luck.

That $5 billion disaster at Tyndall was just one of a mounting number of extreme-weather events that convinced the US Department of Defense that it needed new ideas to protect the 1,700 coastal bases it’s responsible for globally. As hurricanes Helene and Milton have just shown, beachfront residents face compounding threats from climate change, and the Pentagon is no exception. Rising oceans are chewing away the shore. Stronger storms are more capable of flooding land.

In response, Tyndall will later this month test a new way to protect shorelines from intensified waves and storm surges: a prototype artificial reef, designed by a team led by Rutgers University scientists. The 50-meter-wide array, made up of three chevron-shaped structures each weighing about 46,000 pounds, can take 70 percent of the oomph out of waves, according to tests. But this isn’t your grandaddy’s seawall. It’s specifically designed to be colonized by oysters, some of nature’s most effective wave-killers.

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Pamela Goodwin has received hundreds of emails from patients asking if they should take a cheap, readily available drug, metformin, to treat their cancer.

It’s a fair question: Metformin, commonly used to treat diabetes, has been investigated for treating a range of cancer types in thousands of studies on laboratory cells, animals, and people. But Goodwin, an epidemiologist and medical oncologist treating breast cancer at the University of Toronto’s Mount Sinai Hospital, advises against it. No gold-standard trials have proved that metformin helps treat breast cancer—and her recent research suggests it doesn’t.

Metformin’s development was inspired by centuries of use of French lilac, or goat’s rue (Galega officinalis), for diabetes-like symptoms. In 1918, researchers discovered that a compound from the herb lowers blood sugar. Metformin, a chemical relative of that compound, has been a top type 2 diabetes treatment in the United States since it was approved in 1994. It’s cheap—less than a dollar per dose—and readily available, with few side effects. Today, more than 150 million people worldwide take the stuff.

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When satellites first started peering down on the craggy, glaciated Antarctic Peninsula about 40 years ago, they saw only a few tiny patches of vegetation covering a total of about 8,000 square feet—less than a football field.

But since then, the Antarctic Peninsula has warmed rapidly, and a new study shows that mosses, along with some lichen, liverworts and associated algae, have colonized more than 4.6 square miles, an area nearly four times the size of New York’s Central Park.

The findings, published Friday in Nature Geoscience, based on a meticulous analysis of Landsat images from 1986 to 2021, show that the greening trend is distinct from natural variability and that it has accelerated by 30 percent since 2016, fast enough to cover nearly 75 football fields per year.

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There has been a lot of research on the types of people who believe conspiracy theories, and their reasons for doing so. But there’s a wrinkle: My colleagues and I have found that there are a number of people sharing conspiracies online who don’t believe their own content.

They are opportunists. These people share conspiracy theories to promote conflict, cause chaos, recruit and radicalize potential followers, make money, harass, or even just to get attention.

There are several types of this sort of conspiracy-spreader trying to influence you.

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On February 3, 2023, a train carrying chemicals jumped the tracks in East Palestine, Ohio, rupturing railcars filled with hazardous materials and fueling chemical fires at the foothills of the Appalachian Mountains.

The disaster drew global attention as the governors of Ohio and Pennsylvania urged evacuations for a mile around the site. Flames and smoke billowed from burning chemicals, and an acrid odor radiated from the derailment area as chemicals entered the air and spilled into a nearby creek.

Three days later, at the urging of the rail company Norfolk Southern, about 1 million pounds of vinyl chloride, a chemical that can be toxic to humans at high doses, was released from the damaged train cars and set aflame.

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Billions of cells die in your body every day. Some go out with a bang, others with a whimper.

They can die by accident if they’re injured or infected. Alternatively, should they outlive their natural lifespan or start to fail, they can carefully arrange for a desirable demise, with their remains neatly tidied away.

Originally, scientists thought those were the only two ways an animal cell could die, by accident or by that neat-and-tidy version. But over the past couple of decades, researchers have racked up many more novel cellular death scenarios, some specific to certain cell types or situations. Understanding this panoply of death modes could help scientists save good cells and kill bad ones, leading to treatments for infections, autoimmune diseases, and cancer.

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Four years after the outbreak of the COVID-19 pandemic, doctors and researchers are still seeking ways to help patients with long COVID, the persistent and often debilitating symptoms that can continue long after a COVID-19 infection.

In adults, the most common long COVID symptoms include fatigue and brain fog, but for children the condition can look different. A study published last month suggests preteens are more likely to experience symptoms such as headaches, stomach pain, trouble sleeping, and attention difficulties. Even among children, effects seem to vary by age. “There seems to be some differences between age groups, with less signs of organ damage in younger children and more adultlike disease in adolescents,” says Petter Brodin, professor of pediatric immunology at Imperial College London.

While vast sums have been devoted to long COVID research—the US National Institutes of Health have spent more than a billion dollars on research projects and clinical trials—research into children with the condition has been predominantly limited to online surveys, calls with parents, and studies of electronic health records. This is in spite of a recent study suggesting that between 10 and 20 percent of children may have developed long COVID following an acute infection, and another report finding that while many have recovered, some still remain ill three years later.

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On February 3, 2023, a train carrying chemicals jumped the tracks in East Palestine, Ohio, rupturing railcars filled with hazardous materials and fueling chemical fires at the foothills of the Appalachian Mountains.

The disaster drew global attention as the governors of Ohio and Pennsylvania urged evacuations for a mile around the site. Flames and smoke billowed from burning chemicals, and an acrid odor radiated from the derailment area as chemicals entered the air and spilled into a nearby creek.

Three days later, at the urging of the rail company Norfolk Southern, about 1 million pounds of vinyl chloride, a chemical that can be toxic to humans at high doses, was released from the damaged train cars and set aflame.

Read full article

Comments

Billions of cells die in your body every day. Some go out with a bang, others with a whimper.

They can die by accident if they’re injured or infected. Alternatively, should they outlive their natural lifespan or start to fail, they can carefully arrange for a desirable demise, with their remains neatly tidied away.

Originally, scientists thought those were the only two ways an animal cell could die, by accident or by that neat-and-tidy version. But over the past couple of decades, researchers have racked up many more novel cellular death scenarios, some specific to certain cell types or situations. Understanding this panoply of death modes could help scientists save good cells and kill bad ones, leading to treatments for infections, autoimmune diseases, and cancer.

Read full article

Comments

Four years after the outbreak of the COVID-19 pandemic, doctors and researchers are still seeking ways to help patients with long COVID, the persistent and often debilitating symptoms that can continue long after a COVID-19 infection.

In adults, the most common long COVID symptoms include fatigue and brain fog, but for children the condition can look different. A study published last month suggests preteens are more likely to experience symptoms such as headaches, stomach pain, trouble sleeping, and attention difficulties. Even among children, effects seem to vary by age. “There seems to be some differences between age groups, with less signs of organ damage in younger children and more adultlike disease in adolescents,” says Petter Brodin, professor of pediatric immunology at Imperial College London.

While vast sums have been devoted to long COVID research—the US National Institutes of Health have spent more than a billion dollars on research projects and clinical trials—research into children with the condition has been predominantly limited to online surveys, calls with parents, and studies of electronic health records. This is in spite of a recent study suggesting that between 10 and 20 percent of children may have developed long COVID following an acute infection, and another report finding that while many have recovered, some still remain ill three years later.

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Enlarge / Hummingbirds—like this golden-tailed sapphire from South America—draw the eye with their bright colors and busy, hovering flight. Biologists are drawn to understand the suite of adaptations they have evolved to survive extreme lifestyles. (credit: webguzs via Getty)

Everyone loves to watch hummingbirds—tiny, brightly colored blurs that dart about, hovering at flowers and pugnaciously defending their ownership of a feeder.

But to the scientists who study them, hummingbirds offer much more than an entertaining spectacle. Their small size and blazing metabolism mean they live life on a knife-edge, sometimes needing to shut down their bodies almost completely just to conserve enough energy to survive the night—or to migrate thousands of miles, at times across open ocean.

Their nectar-rich diet leads to blood-sugar levels that would put a person in a coma. And their zipping, zooming flight sometimes generates g-forces high enough to make a fighter pilot black out. The more researchers look, the more surprises lurk within those tiny bodies, the smallest in the avian world.

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(credit: USGS)

Droughts in the coming decades could be longer than projected by current climate models, a new study published Wednesday in Nature warns.

The international team of scientists examined potential biases that could skew climate models used to make drought projections under Intergovernmental Panel on Climate Change midrange and high emissions scenarios. The researchers corrected for the bias by calibrating those models with observations of the longest annual dry spells between 1998 and 2018.

By the end of this century, they found that the average longest periods of drought could be 10 days longer than previously projected. Trouble spots included North America, Southern Africa, and Madagascar, where the newly calibrated models showed that the increase in the longest annual dry spell could be about twice what the older models predicted.

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Enlarge (credit: Jason Edwards via Getty)

Earthquake scientists detected an unusual signal on monitoring stations used to detect seismic activity during September 2023. We saw it on sensors everywhere, from the Arctic to Antarctica.

We were baffled—the signal was unlike any previously recorded. Instead of the frequency-rich rumble typical of earthquakes, this was a monotonous hum, containing only a single vibration frequency. Even more puzzling was that the signal kept going for nine days.

Initially classified as a “USO”—an unidentified seismic object—the source of the signal was eventually traced back to a massive landslide in Greenland’s remote Dickson Fjord. A staggering volume of rock and ice, enough to fill 10,000 Olympic-sized swimming pools, plunged into the fjord, triggering a 200-meter-high mega-tsunami and a phenomenon known as a seiche: a wave in the icy fjord that continued to slosh back and forth, some 10,000 times over nine days.

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