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When ribosomes go rogue

In the 1940s, scientists at the recently established National Cancer Institute were trying to breed mice that could inform our understanding of cancer, either because they predictably developed certain cancers or were surprisingly resistant.

The team spotted a peculiar litter in which some baby mice had short, kinked tails and misplaced ribs growing out of their neck bones. The strain of mice, nicknamed “tail short,” has been faithfully bred ever since, in the hope that one day, research might reveal what was the matter with them.

After more than 60 years, researchers finally got their answer, when Maria Barna, a developmental biologist then at the University of California San Francisco, found that the mice had a genetic mutation that caused a protein to disappear from their ribosomes—the places in cells where proteins are made.

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Studies of migraine’s many triggers offer paths to new therapies

For Cherise Irons, chocolate, red wine, and aged cheeses are dangerous. So are certain sounds, perfumes and other strong scents, cold weather, and thunderstorms. Stress and lack of sleep, too.

She suspects all of these things can trigger her migraine attacks, which manifest in a variety of ways: pounding pain in the back of her head, exquisite sensitivity to the slightest sound, even blackouts and partial paralysis.

Irons, 48, of Coral Springs, Florida, once worked as a school assistant principal. Now, she’s on disability due to her migraine. Irons has tried so many migraine medications she’s lost count—but none has helped for long. Even a few of the much-touted new drugs that have quelled episodes for many people with migraine have failed for Irons.

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Sustainable building effort reaches new heights with wooden skyscrapers

At the University of Toronto, just across the street from the football stadium, workers are putting up a 14-story building with space for classrooms and faculty offices. What’s unusual is how they’re building it — by bolting together giant beams, columns, and panels made of manufactured slabs of wood.

As each wood element is delivered by flatbed, a tall crane lifts it into place and holds it in position while workers attach it with metal connectors. In its half-finished state, the building resembles flat-pack furniture in the process of being assembled.

The tower uses a new technology called mass timber. In this kind of construction, massive, manufactured wood elements that can extend more than half the length of a football field replace steel beams and concrete. Though still relatively uncommon, it is growing in popularity and beginning to pop up in skylines around the world.

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Why a diabetes drug fell short of anticancer hopes

Pamela Goodwin has received hundreds of emails from patients asking if they should take a cheap, readily available drug, metformin, to treat their cancer.

It’s a fair question: Metformin, commonly used to treat diabetes, has been investigated for treating a range of cancer types in thousands of studies on laboratory cells, animals, and people. But Goodwin, an epidemiologist and medical oncologist treating breast cancer at the University of Toronto’s Mount Sinai Hospital, advises against it. No gold-standard trials have proved that metformin helps treat breast cancer—and her recent research suggests it doesn’t.

Metformin’s development was inspired by centuries of use of French lilac, or goat’s rue (Galega officinalis), for diabetes-like symptoms. In 1918, researchers discovered that a compound from the herb lowers blood sugar. Metformin, a chemical relative of that compound, has been a top type 2 diabetes treatment in the United States since it was approved in 1994. It’s cheap—less than a dollar per dose—and readily available, with few side effects. Today, more than 150 million people worldwide take the stuff.

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Your cells are dying. All the time.

Billions of cells die in your body every day. Some go out with a bang, others with a whimper.

They can die by accident if they’re injured or infected. Alternatively, should they outlive their natural lifespan or start to fail, they can carefully arrange for a desirable demise, with their remains neatly tidied away.

Originally, scientists thought those were the only two ways an animal cell could die, by accident or by that neat-and-tidy version. But over the past couple of decades, researchers have racked up many more novel cellular death scenarios, some specific to certain cell types or situations. Understanding this panoply of death modes could help scientists save good cells and kill bad ones, leading to treatments for infections, autoimmune diseases, and cancer.

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Your cells are dying. All the time.

Billions of cells die in your body every day. Some go out with a bang, others with a whimper.

They can die by accident if they’re injured or infected. Alternatively, should they outlive their natural lifespan or start to fail, they can carefully arrange for a desirable demise, with their remains neatly tidied away.

Originally, scientists thought those were the only two ways an animal cell could die, by accident or by that neat-and-tidy version. But over the past couple of decades, researchers have racked up many more novel cellular death scenarios, some specific to certain cell types or situations. Understanding this panoply of death modes could help scientists save good cells and kill bad ones, leading to treatments for infections, autoimmune diseases, and cancer.

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Hummingbirds thrive on an extreme lifestyle. Here’s how.

26 September 2024 at 13:29
Golden-Tailed Sapphire Hummingbird about to extract nectar from a yellow and red flower

Enlarge / Hummingbirds—like this golden-tailed sapphire from South America—draw the eye with their bright colors and busy, hovering flight. Biologists are drawn to understand the suite of adaptations they have evolved to survive extreme lifestyles. (credit: webguzs via Getty)

Everyone loves to watch hummingbirds—tiny, brightly colored blurs that dart about, hovering at flowers and pugnaciously defending their ownership of a feeder.

But to the scientists who study them, hummingbirds offer much more than an entertaining spectacle. Their small size and blazing metabolism mean they live life on a knife-edge, sometimes needing to shut down their bodies almost completely just to conserve enough energy to survive the night—or to migrate thousands of miles, at times across open ocean.

Their nectar-rich diet leads to blood-sugar levels that would put a person in a coma. And their zipping, zooming flight sometimes generates g-forces high enough to make a fighter pilot black out. The more researchers look, the more surprises lurk within those tiny bodies, the smallest in the avian world.

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Air pollution makes it harder for bees to smell flowers

29 July 2024 at 18:34
Scientists are uncovering various ways that air pollution can interfere with the ability of insects to pollinate plants.

Scientists are uncovering various ways that air pollution can interfere with the ability of insects to pollinate plants. (credit: Utah.gov)

In the summers of 2018 and 2019, ecologist James Ryalls and his colleagues would go out to a field near Reading in southern England to stare at the insects buzzing around black mustard plants. Each time a bee, hoverfly, moth, butterfly, or other insect tried to get at the pollen or nectar in the small yellow flowers, they’d make a note.

It was part of an unusual experiment. Some patches of mustard plants were surrounded by pipes that released ozone and nitrogen oxides—polluting gases produced around power plants and conventional cars. Other plots had pipes releasing normal air.

The results startled the scientists. Plants smothered by pollutants were visited by up to 70 percent fewer insects overall, and their flowers received 90 percent fewer visits compared with those in unpolluted plots. The concentrations of pollutants were well below what US regulators consider safe. “We didn’t expect it to be quite as dramatic as that,” says study coauthor Robbie Girling, an entomologist at the University of Southern Queensland in Australia and a visiting professor at the University of Reading.

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Are you a workaholic? Here’s how to spot the signs

28 July 2024 at 11:02
Man works late in dimly lit cubicle amid a dark office space

Enlarge (credit: Bill Varie/Getty Images)

An accountant who fills out spreadsheets at the beach, a dog groomer who always has time for one more client, a basketball player who shoots free throws to the point of exhaustion.

Every profession has its share of hard chargers and overachievers. But for some workers—perhaps more than ever in our always-on, always-connected world—the drive to send one more email, clip one more poodle, sink one more shot becomes all-consuming.

Workaholism is a common feature of the modern workplace. A recent review gauging its pervasiveness across occupational fields and cultures found that roughly 15 percent of workers qualify as workaholics. That adds up to millions of overextended employees around the world who don’t know when—or how, or why—to quit.

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It’s not just us: Other animals change their social habits in old age

27 July 2024 at 11:08
A Rhesus macaque on a Buddhist stupa in the Swayambhunath temple complex in Kathmandu, Nepal

Enlarge / As female macaques age, the size of their social network shrinks. (credit: Jon G. Fuller/VW Pics/Universal Images Group via Getty Images)

Walnut was born on June 3, 1995, at the start of what would become an unusually hot summer, on an island called Rum (pronounced room), the largest of the Small Isles off the west coast of Scotland. We know this because since 1974, researchers have diligently recorded the births of red deer like her, and caught, weighed and marked every calf they could get their hands on—about 9 out of every 10.

Near the cottage in Kilmory on the northern side of the island where the researchers are based, there has been no hunting since the project began, which allowed the deer to relax and get used to human observers. Walnut was a regular there, grazing the invariably short-clipped grass in this popular spot. “She would always just be there in the group, with her sisters and their families,” says biologist Alison Morris, who has lived on Rum for more than 23 years and studies the deer year-round.

Walnut raised 14 offspring, the last one in 2013, when she was 18 years old. In her later years, Morris recalls, Walnut would spend most of her time away from the herd, usually with Vanity, another female (called a hind) of the same age who had never calved. “They were often seen affectionately grooming each other, and after Walnut died of old age in October 2016, at the age of 21—quite extraordinary for a hind—Vanity spent most of her time alone. She died two years later, at the grand age of 23.”

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Animals use physics? Let us count the ways

14 July 2024 at 11:13
kitten latches on to a pole with its two front paws

Enlarge (credit: Fernando Trabanco Fotografía via Getty Images)

Isaac Newton would never have discovered the laws of motion had he studied only cats.

Suppose you hold a cat, stomach up, and drop it from a second-story window. If a cat is simply a mechanical system that obeys Newton’s rules of matter in motion, it should land on its back. (OK, there are some technicalities—like this should be done in a vacuum, but ignore that for now.) Instead, most cats usually avoid injury by twisting themselves on the way down to land on their feet.

Most people are not mystified by this trick—everybody has seen videos attesting to cats’ acrobatic prowess. But for more than a century, scientists have wondered about the physics of how cats do it. Clearly, the mathematical theorem analyzing the falling cat as a mechanical system fails for live cats, as Nobel laureate Frank Wilczek points out in a recent paper.

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To help with climate change, carbon capture will have to evolve

11 July 2024 at 11:11
Image of a facility filled with green-colored tubes.

Enlarge / Bioreactors that host algae would be one option for carbon sequestration—as long as the carbon is stored somehow. (credit: Getty Images)

More than 200 kilometers off Norway’s coast in the North Sea sits the world’s first offshore carbon capture and storage project. Built in 1996, the Sleipner project strips carbon dioxide from natural gas—largely made up of methane—to make it marketable. But instead of releasing the CO2 into the atmosphere, the greenhouse gas is buried.

The effort stores around 1 million metric tons of CO2 per year—and is praised by many as a pioneering success in global attempts to cut greenhouse gas emissions.

Last year, total global CO2 emissions hit an all-time high of around 35.8 billion tons, or gigatons. At these levels, scientists estimate, we have roughly six years left before we emit so much CO2 that global warming will consistently exceed 1.5° Celsius above average preindustrial temperatures, an internationally agreed-upon limit. (Notably, the global average temperature for the past 12 months has exceeded this threshold.)

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The greening of planes, trains, and automobiles

The greening of planes, trains, and automobiles

Enlarge (credit: Petmal / Getty Images)

As the world races to decarbonize everything from the electricity grid to industry, it faces particular problems with transportation—which alone is responsible for about a quarter of our planet’s energy-related greenhouse gas emissions. The fuels for transport need to be not just green, cheap, and powerful, but also lightweight and safe enough to be carried around.

Fossil fuels—mainly gasoline and diesel—have been extraordinarily effective at powering a diverse range of mobile machines. Since the Industrial Revolution, humanity has perfected the art of dredging these up, refining them, distributing them and combusting them in engines, creating a vast and hard-to-budge industry. Now we have to step away from fossil fuels, and the world is finding no one-size-fits-all replacement.

Each type of transportation has its own peculiarities—which is one reason we have different formulations of hydrocarbons today, from gasoline to diesel, bunker fuel to jet fuel. Cars need a convenient, lightweight power source; container ships need enough oomph to last months; planes absolutely need to be reliable and to work at subzero temperatures. As the fossil fuels are phased out, the transport fuel landscape is “getting more diverse,” says Timothy Lipman, co-director of the Transportation Sustainability Research Center at the University of California, Berkeley.

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Nature interrupted: Impact of the US-Mexico border wall on wildlife

30 June 2024 at 11:15
This aerial picture taken on December 8, 2023, shows the US-Mexico border wall in Sasabe, Arizona.

Enlarge / This aerial picture taken on December 8, 2023, shows the US-Mexico border wall in Sasabe, Arizona. (credit: VALERIE MACON/AFP via Getty Images)

In a vast stretch of the Sonoran Desert, between the towns of San Luis Río Colorado and Sonoyta in northern Mexico, sits a modest building of cement, galvanized sheet metal, and wood—the only stop along 125 miles of inhospitable landscape dominated by thorny ocotillo shrubs and towering saguaro cactuses up to 50 feet high. It’s a fonda—a small restaurant—called La Liebre del Desierto (The Desert Hare), and for more than 20 years, owner Elsa Ortiz Ramos has welcomed and nourished weary travelers taking a break from the adjacent highway that runs through the arid Pinacate and Grand Desierto de Altar Biosphere Reserve.

But the dedication and care of this petite woman go beyond her simple menu. Every two weeks, she pays out of pocket for a 5,000-gallon tank of water to distribute to a network of water troughs strategically placed in the area. By doing so, she relieves the thirst of bighorn sheep, ocelots, pronghorn, coyotes, deer, and even bats that have been deprived of access to their natural water sources.

“The crows come to the house and scream to warn us that there is no more water ... it’s our alarm,” says Ortiz Ramos in her distinct northern Mexico accent. Her words sound straight from an Aesop’s fable, but they take on stark realism in this spot. Covering large parts of Arizona, California, and the Mexican states of Baja California and Sonora, the Sonoran Desert—along with the Lut Desert in Iran—was cataloged in 2023 as having the hottest surface temperature on the planet, at 80.8° Celsius (177° Fahrenheit).

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Radioactive drugs strike cancer with precision

21 June 2024 at 10:30
Pharma interest and investment in radiotherapy drugs is heating up.

Enlarge / Pharma interest and investment in radiotherapy drugs is heating up. (credit: Knowable Magazine)

On a Wednesday morning in late January 1896 at a small light bulb factory in Chicago, a middle-aged woman named Rose Lee found herself at the heart of a groundbreaking medical endeavor. With an X-ray tube positioned above the tumor in her left breast, Lee was treated with a torrent of high-energy particles that penetrated into the malignant mass.

“And so,” as her treating clinician later wrote, “without the blaring of trumpets or the beating of drums, X-ray therapy was born.”

Radiation therapy has come a long way since those early beginnings. The discovery of radium and other radioactive metals opened the doors to administering higher doses of radiation to target cancers located deeper within the body. The introduction of proton therapy later made it possible to precisely guide radiation beams to tumors, thus reducing damage to surrounding healthy tissues—a degree of accuracy that was further refined through improvements in medical physics, computer technologies and state-of-the-art imaging techniques.

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Cleaning up cow burps to combat global warming

20 June 2024 at 16:20
Cleaning up cow burps to combat global warming

Enlarge (credit: Tony C. French/Getty)

In the urgent quest for a more sustainable global food system, livestock are a mixed blessing. On the one hand, by converting fibrous plants that people can’t eat into protein-rich meat and milk, grazing animals like cows and sheep are an important source of human food. And for many of the world’s poorest, raising a cow or two—or a few sheep or goats—can be a key source of wealth.

But those benefits come with an immense environmental cost. A study in 2013 showed that globally, livestock account for about 14.5 percent of greenhouse gas emissions, more than all the world’s cars and trucks combined. And about 40 percent of livestock’s global warming potential comes in the form of methane, a potent greenhouse gas formed as they digest their fibrous diet.

That dilemma is driving an intense research effort to reduce methane emissions from grazers. Existing approaches, including improved animal husbandry practices and recently developed feed additives, can help, but not at the scale needed to make a significant global impact. So scientists are investigating other potential solutions, such as breeding low-methane livestock and tinkering with the microbes that produce the methane in grazing animals’ stomachs. While much more research is needed before those approaches come to fruition, they could be relatively easy to implement widely and could eventually have a considerable impact.

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A scientific mission to save the sharks

15 June 2024 at 11:07
A scientific mission to save the sharks

Enlarge (credit: RamonCarretero/Getty)

A hammerhead shark less than one meter long swims frantically in a plastic container aboard a boat in the Sanquianga National Natural Park, off Colombia’s Pacific coast. It is a delicate female Sphyrna corona, the world’s smallest hammerhead species, and goes by the local name cornuda amarilla—yellow hammerhead—because of the color of its fins and the edges of its splendid curved head, which is full of sensors to perceive the movement of its prey.

Marine biologist Diego Cardeñosa of Florida International University, along with local fishermen, has just captured the shark and implanted it with an acoustic marker before quickly returning it to the murky waters. A series of receivers will help to track its movements for a year, to map the coordinates of its habitat—valuable information for its protection.

That hammerhead is far from the only shark species that keeps the Colombian biologist busy. Cardeñosa’s mission is to build scientific knowledge to support shark conservation, either by locating the areas where the creatures live or by identifying, with genetic tests, the species that are traded in the world’s main shark markets.

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To pee or not to pee? That is a question for the bladder—and the brain

Cut view of man covering urine with hands. He has some pain and problem. Isolated on striped and blue background

Enlarge (credit: Estradaanton/Getty Images)

You’re driving somewhere, eyes on the road, when you start to feel a tingling sensation in your lower abdomen. That extra-large Coke you drank an hour ago has made its way through your kidneys into your bladder. “Time to pull over,” you think, scanning for an exit ramp.

To most people, pulling into a highway rest stop is a profoundly mundane experience. But not to neuroscientist Rita Valentino, who has studied how the brain senses, interprets, and acts on the bladder’s signals. She’s fascinated by the brain’s ability to take in sensations from the bladder, combine them with signals from outside of the body, like the sights and sounds of the road, then use that information to act—in this scenario, to find a safe, socially appropriate place to pee. “To me, it’s really an example of one of the beautiful things that the brain does,” she says.

Scientists used to think that our bladders were ruled by a relatively straightforward reflex—an “on-off” switch between storing urine and letting it go. “Now we realize it’s much more complex than that,” says Valentino, now director of the division of neuroscience and behavior at the National Institute of Drug Abuse. An intricate network of brain regions that contribute to functions like decision-making, social interactions, and awareness of our body’s internal state, also called interoception, participates in making the call.

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The hornet has landed: Scientists combat new honeybee killer in US

2023 marked the first sighting of a yellow-legged hornet in the United States, sparking fears that it may spread and devastate honeybees as it has in parts of Europe.

Enlarge / 2023 marked the first sighting of a yellow-legged hornet in the United States, sparking fears that it may spread and devastate honeybees as it has in parts of Europe. (credit: Miguel Riopa/AFP via Getty Images)

In early August 2023, a beekeeper near the port of Savannah, Georgia, noticed some odd activity around his hives. Something was hunting his honeybees. It was a flying insect bigger than a yellowjacket, mostly black with bright yellow legs. The creature would hover at the hive entrance, capture a honeybee in flight, and butcher it before darting off with the bee’s thorax, the meatiest bit.

“He’d only been keeping bees since March… but he knew enough to know that something wasn’t right with this thing,” says Lewis Bartlett, an evolutionary ecologist and honeybee expert at the University of Georgia, who helped to investigate. Bartlett had seen these honeybee hunters before, during his PhD studies in England a decade earlier. The dreaded yellow-legged hornet had arrived in North America.

With origins in Afghanistan, eastern China, and Indonesia, the yellow-legged hornet, Vespa velutina, has expanded during the last two decades into South Korea, Japan, and Europe. When the hornet invades new territory, it preys on honeybees, bumblebees, and other vulnerable insects. One yellow-legged hornet can kill up to dozens of honeybees in a single day. It can decimate colonies through intimidation by deterring honeybees from foraging. “They’re not to be messed with,” says honeybee researcher Gard Otis, professor emeritus at the University of Guelph in Canada.

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