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Study: Cats in little crocheted hats shed light on feline chronic pain

✇Science – Ars Technica
Jennifer Ouellette

Our feline overlords aren't particularly known for obeying commands from mere humans, which can make it difficult to study their behaviors in controlled laboratory settings. So a certain degree of ingenuity is required to get usable results—like crocheting adorable little hats for kitties taking part in electroencephalogram (EEG) experiments. That's what researchers at the University of Montreal in Quebec, Canada, did to learn more about assessing chronic pain in cats—and they succeeded. According to their recent paper published in the Journal of Neuroscience Methods, it's the first time scientists have recorded the electrical activity in the brains of conscious cats.

According to the authors, one-quarter of adult cats suffer from osteoarthritis and chronic pain that worsens with age. There are currently limited treatment options, namely, non-steroidal anti-inflammatory drugs, which can have significant side effects for the cats. An injectable monoclonal antibody tailored for cats has recently been developed to neutralize excessive nerve growth factor, but other alternative treatment options like supplements and regenerative medicine have yet to be tested. Nor has the effectiveness of certain smells or lighting in altering pain perception in felines been tested.

That was the Montreal team's primary objective for their experiments. Initially, they tried to place electrodes on the heads of 11 awake adult cats with osteoarthritis, but the cats kept shaking off the electrodes.

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Ars chats with Precision, the brain-chip maker taking the road less invasive

✇Science – Ars Technica
Beth Mole
Precision’s Layer 7 Cortical Interface array.

Enlarge / Precision’s Layer 7 Cortical Interface array. (credit: Precision)

Work toward brain-computer interfaces has never been more charged. Though neuroscientists have toiled for decades to tap directly into human thoughts, recent advances have the field buzzing with anticipation—and the involvement of one polarizing billionaire has drawn a new level of attention.

With competition amping up in this space, Ars spoke with Ben Rapoport, who is a neurosurgeon, electrical engineer, and co-founder of the brain-computer interface (BCI) company Precision Neuroscience. Precision is at the forefront of the field, having placed its BCI on the brains of 14 human patients so far, with two more scheduled this month. Rapoport says he hopes to at least double that number of human participants by the end of this year. In fact, the 3-year-old company expects to have its first BCI on the market next year.

In addition to the swift progress, Precision is notable for its divergence from its competitor's strategies, namely Neuralink, the most high-profile BCI company and headed by Elon Musk. In 2016, Rapoport co-founded Neuralink alongside Musk and other scientists. But he didn't stay long and went on to co-found Precision in 2021. In previous interviews, Rapoport suggested his split from Neuralink related to the issues of safety and invasiveness of the BCI design. While Neuralink's device is going deeper into the brain—trying to eavesdrop on neuron signals with electrodes at close range to decode thoughts and intended motions and speech—Precision is staying at the surface, where there is little to no risk of damaging brain tissue.

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